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FDA Information

Trazodone was approved by the U.S. FDA in 1982.

The FDA recently advised that trazodone be used with caution in patients receiving amprenavir. If this drug combination is used, a lower dose of trazodone should be considered. Concomitant use of trazodone and amprenavir (with or without ritonavir) may result in increased trazodone plasma concentrations and adverse events, such as nausea, dizziness, hypotension, and syncope.

 

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