Tell your doctor and pharmacist if you are allergic to trazodone or any other medications.

Inform your doctor and pharmacist what other prescription and non-prescription medications, vitamins, and nutritional supplements you are taking. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); antidepressants, especially selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, Sarafem) and fluvoxamine (Luvox); antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); cimetidine (Tagamet); clarithromycin (Biaxin, Prevpac); cyclosporine (Neoral, Sandimmune); danazol (Danocrine); delaviridine (Rescriptor); dexamethasone (Decadron); digoxin (Digitek, Lanoxin, Lanoxicaps); diltiazem (Cardizem, Dilacor, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Fortovase, Invirase); isoniazid (INH, Nydrazid); medications for allergies, cough or colds; medications for anxiety, high blood pressure, irregular heartbeat, mental illness or pain; medication for seizures such as carbamazepine (Tegretol), ethosuximide (Zarontin), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin); metronidazole (Flagyl); muscle relaxants; nefazodone; oral contraceptives (birth control pills); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); sedatives; sleeping pills; tranquilizers; troleandomycin (TAO); verapamil (Calan, Isoptin, Verelan); or zafirlukast (Accolate).

Also, tell your doctor or pharmacist if you are taking the following medications, called MAO inhibitors, or if you have stopped taking them within the past two weeks: isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Carbex), or tranylcypromine (Parnate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

Tell your doctor what herbal products you are taking, especially St. John's wort.

Tell your doctor if you or anyone in your family has or has ever had depression, bipolar disorder (mood that changes from depressed to abnormally excited), or mania (frenzied, abnormally excited mood), or if you or anyone in your family has thought about or attempted suicide.

Also, inform your doctor if you are being treated with electroshock therapy and if you have or have ever had cancer, a heart attack, irregular heart beat, high blood pressure, human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDs), low white blood cell count, or heart disease.

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking trazodone, call your doctor.

If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking trazodone.

You should know that trazodone may make you drowsy and affect your judgment. Do not drive a car or operate machinery until you know how this medication affects you. If drowsiness is a problem, ask your doctor about taking part of your dose at bedtime.

Ask your doctor about the safe use of alcoholic beverages while you are taking trazodone. Alcohol can make the side effects from trazodone worse.

NOTE - You should know that your mental health may change in unexpected ways, especially at the beginning of your treatment and any time that your dose is increased or decreased. These changes may occur at any time if you have depression or another mental illness, whether or not you are taking trazodone or any other medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied, abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own.

You should know that trazodone may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

Studies have shown that children and teenagers who take antidepressants such as trazodone may be more likely to think about harming or killing themselves or to plan or try to do so.

 

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